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WAVE Single-use Bioreactor For Cell Culture

WAVE Series

The WAVE disposable bioreactor has great advantages in the personalized treatment of cell medicines. For example, the use of disposable culture bags can allow the same equipment to meet the cultivation of cells on various platforms, avoid cross-contamination, and improve production efficiency. Compared with the traditional stirred bioreactor, the WAVE bioreactor makes the medium in the culture bag wave during the rocking process, which increases the contact area between the gas and the liquid surface, and promotes the transfer of nutrients and the efficiency of oxygen exchange. This gentle and efficient mixing method avoids the damage of the high shear force of the stirring paddle to the cells and can also significantly improve the oxygen mass transfer coefficient. In this culture method, the cell growth rate is faster and the density is higher.

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OVERVIEW

Consumables needed for WAVE disposable reactor: including cell bags, liquid storage bags, hoses, filters and tangential flow membranes, etc., usually made of medical grade plastic materials (such as polyethylene, polycarbonate, polystyrene, etc.) , sterilized by gamma rays in advance can effectively prevent pollution and realize ready-to-use. Compared with traditional stainless steel reactors, this method reduces the sterilization process and the dependence on other public facilities (such as water systems and steam, etc.) , saving plant construction and construction costs, reducing the difficulty of plant construction, and significantly reducing production cost input.

The use of consumables such as disposable reactors can also reduce the company's training costs for employees, such as training on the use of public facilities, cleaning and sterilization, and subsequent verification, reducing employee operating errors and shortening the drug production cycle. The WAVE disposable bioreactor also reduces the possibility of cells being exposed to the external environment of the laboratory multiple times during the culture period. Sterile disposable tubing and transfer bags are used in the inoculation, feeding, sampling and transfer processes. To a great extent, it meets the requirements of GMP production for a closed environment, and shortens the time to market of pharmaceutical products while complying with regulations.

PROJECT CASE

bioreactor fermenter project case